Why do people increasingly take on old age?

Many people have problems maintaining a healthy body weight, especially at an older age. Researchers have now found that fat metabolism in adipose tissue decreases with age, which facilitates weight gain.

The recent study by Uppsala University, the University of Lyon and Karolinska Institutet, Stockholm has now found that in old age fat metabolism in adipose tissue decreases. The results of the study were published in the English language journal "Nature Medicine".

Generally, people gain weight faster in old age, which can lead to overweight and obesity. (Image: PeJo / fotolia.com)

Average weight gain of 20 percent noted

As fat decreases in adipose tissue as you age, it makes it easier to gain weight even when people stop eating or do the same amount of exercise as before. The researchers came to this conclusion when examining the fat cells of 54 men and women over an average period of 13 years. During this time, all participants, regardless of whether they had increased or decreased, showed a decrease in lipid turnover in adipose tissue. In other words, the speed at which lipid (fat) in fat cells is removed and stored was reduced. If this was not compensated by a reduced calorie intake, the affected individuals increased on average by 20 percent. The researchers also investigated lipid turnover in 41 bariatric women and how the lipid turnover rate affected their weight four to seven years after the operation. It was found that only those women who already had a low lipid conversion rate prior to surgery increased their lipid metabolism and achieved a higher weight loss.

New ways to treat obesity?

"The results show for the first time that processes in our adipose tissue regulate changes in body weight during aging in ways that are independent of other factors," says study author Professor Peter Arner of Karolinska Institutet in a press release. This could open up new ways to treat obesity.

How can the lipid turnover in fatty tissue be accelerated?

Previous studies had already shown that more exercise is one way to accelerate lipid turnover in adipose tissue. The new research supports this notion, suggesting that the long-term outcome of bariatric surgery would also improve if combined with increased physical activity. Obesity and diseases related to obesity have become a global problem. The understanding of the so-called lipid dynamics and the regulation of fat mass in humans has therefore never been so important, says study author Kirsty Spaldin from Karolinska Institutet. (As)


  • P. Arner, S. Bernard, L. Appelsved, K.-Y. Fu, D.P. Andersson et al .: Adipose lipid turnover and long-term changes in body weight, in Nature Medicine (query: 11.09.2019), Nature Medicine
  • New study shows why people gain weight as they get older, Karolinska Institutet (query: 11.09.2019), Karolinska Institutet

Important NOTE:
This article contains only general information and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.

. (TagsToTranslate) weight gain (t) age (t) overweight (t) obesity (t) lipid turnover


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